Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet
Joint Authors
Ge, Aiguo
Wang, Xiaoke
Yang, Nianhong
Zhou, Xiaoqi
Cheng, Mengjie
Liu, Liegang
Guo, Fangfang
Zhao, Min
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammation has been implicated in the hypothalamic leptin and insulin resistance resulting defective food intake during high fat diet period.
To investigate hypothalamic inflammation in dietary induced obesity (DIO) and obesity resistant (DIO-R) rats, we established rat models of DIO and DIO-R by feeding high fat diet for 10 weeks.
Then we switched half of DIO and DIO-R rats to chow food and the other half to high fat diet for the following 8 weeks to explore hypothalamic inflammation response to the low fat diet intervention.
Body weight, caloric intake, HOMA-IR, as well as the mRNA expression of hypothalamic TLR4, NF-κB, TNF-α, IL-1β, and IL-6 in DIO/HF rats were significantly increased compared to DIO-R/HF and CF rats, whereas IL-10 mRNA expression was lower in both DIO/HF and DIO-R/HF rats compared with CF rats.
Switching to chow food from high fat diet reduced the body weight and improved insulin sensitivity but not affecting the expressions of studied inflammatory genes in DIO rats.
Take together, upregulated hypothalamic inflammation may contribute to the overeating and development of obesity susceptibility induced by high fat diet.
Switching to chow food had limited role in correcting hypothalamic inflammation in DIO rats during the intervention period.
American Psychological Association (APA)
Wang, Xiaoke& Ge, Aiguo& Cheng, Mengjie& Guo, Fangfang& Zhao, Min& Zhou, Xiaoqi…[et al.]. 2012. Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502952
Modern Language Association (MLA)
Wang, Xiaoke…[et al.]. Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502952
American Medical Association (AMA)
Wang, Xiaoke& Ge, Aiguo& Cheng, Mengjie& Guo, Fangfang& Zhao, Min& Zhou, Xiaoqi…[et al.]. Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502952