Myasthenia Gravis : A Review of Available Treatment Approaches

Joint Authors

Hoff, Jana Midelfart
Skeie, Geir Olve
Gilhus, Nils Erik
Romi, Fredrik
Aarli, Johan A.
Owe, Jone F.

Source

Autoimmune Diseases

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-10-05

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

Patients with autoimmune myasthenia gravis (MG) should be further classified before initiating therapy, as treatment response varies for ocular versus generalised, early onset versus late onset, and acetylcholine receptor antibody positive versus MuSK antibody positive disease.

Most patients need immunosuppression in addition to symptomatic therapy.

Prednisolone and azathioprine represent first choice drugs, whereas several second choice options are recommended and should be considered.

Thymectomy should be undertaken in MG with thymoma and in generalised, early-onset MG.

For MG crises and other acute exacerbations, intravenous immunoglobulin (IvIg) and plasma exchange are equally effective and safe treatments.

Children and females in child bearing age need special attention regarding potential side effects of immunosuppressive therapy.

MG pathogenesis is known in detail, but the immune therapy is still surprisingly unspecific, without a pin-pointed attack on the defined disease-inducing antigen-antibody reaction being available.

American Psychological Association (APA)

Gilhus, Nils Erik& Owe, Jone F.& Hoff, Jana Midelfart& Romi, Fredrik& Skeie, Geir Olve& Aarli, Johan A.. 2011. Myasthenia Gravis : A Review of Available Treatment Approaches. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-502963

Modern Language Association (MLA)

Gilhus, Nils Erik…[et al.]. Myasthenia Gravis : A Review of Available Treatment Approaches. Autoimmune Diseases No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-502963

American Medical Association (AMA)

Gilhus, Nils Erik& Owe, Jone F.& Hoff, Jana Midelfart& Romi, Fredrik& Skeie, Geir Olve& Aarli, Johan A.. Myasthenia Gravis : A Review of Available Treatment Approaches. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-502963

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-502963