Myasthenia Gravis : A Review of Available Treatment Approaches
Joint Authors
Hoff, Jana Midelfart
Skeie, Geir Olve
Gilhus, Nils Erik
Romi, Fredrik
Aarli, Johan A.
Owe, Jone F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Patients with autoimmune myasthenia gravis (MG) should be further classified before initiating therapy, as treatment response varies for ocular versus generalised, early onset versus late onset, and acetylcholine receptor antibody positive versus MuSK antibody positive disease.
Most patients need immunosuppression in addition to symptomatic therapy.
Prednisolone and azathioprine represent first choice drugs, whereas several second choice options are recommended and should be considered.
Thymectomy should be undertaken in MG with thymoma and in generalised, early-onset MG.
For MG crises and other acute exacerbations, intravenous immunoglobulin (IvIg) and plasma exchange are equally effective and safe treatments.
Children and females in child bearing age need special attention regarding potential side effects of immunosuppressive therapy.
MG pathogenesis is known in detail, but the immune therapy is still surprisingly unspecific, without a pin-pointed attack on the defined disease-inducing antigen-antibody reaction being available.
American Psychological Association (APA)
Gilhus, Nils Erik& Owe, Jone F.& Hoff, Jana Midelfart& Romi, Fredrik& Skeie, Geir Olve& Aarli, Johan A.. 2011. Myasthenia Gravis : A Review of Available Treatment Approaches. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-502963
Modern Language Association (MLA)
Gilhus, Nils Erik…[et al.]. Myasthenia Gravis : A Review of Available Treatment Approaches. Autoimmune Diseases No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-502963
American Medical Association (AMA)
Gilhus, Nils Erik& Owe, Jone F.& Hoff, Jana Midelfart& Romi, Fredrik& Skeie, Geir Olve& Aarli, Johan A.. Myasthenia Gravis : A Review of Available Treatment Approaches. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-502963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502963