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Type I Interferons : Key Players in Normal Skin and Select Cutaneous Malignancies
Joint Authors
Source
Dermatology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types.
Type I Interferons include IFN-α and IFN-β.
Currently, IFN-α has numerous approved antitumor applications, including malignant melanoma, in which IFN-α has been shown to increase relapse free survival.
Moreover, IFN-α has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).
In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise anti-tumor action of IFN-α/β at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma.
This review summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and immune function in normal skin, cutaneous SCC, BCC, and melanoma.
American Psychological Association (APA)
Ismail, Aimen& Yusuf, Nabiha. 2014. Type I Interferons : Key Players in Normal Skin and Select Cutaneous Malignancies. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-502978
Modern Language Association (MLA)
Ismail, Aimen& Yusuf, Nabiha. Type I Interferons : Key Players in Normal Skin and Select Cutaneous Malignancies. Dermatology Research and Practice No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-502978
American Medical Association (AMA)
Ismail, Aimen& Yusuf, Nabiha. Type I Interferons : Key Players in Normal Skin and Select Cutaneous Malignancies. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-502978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502978