MicroRNA Regulation of Cholesterol Metabolism
Joint Authors
Rotllan, Noemi
Fernández-Hernando, Carlos
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Disruption of cellular cholesterol balance results in pathologic processes including atherosclerosis, metabolic syndrome, type II diabetes and Alzheimer’s disease.
Maintenance of cholesterol homeostasis requires constant metabolic adjustment, achieved partly through the fine regulation of the classical transcription factors (e.g., by SREBP and LXR), but also through members of a class of noncoding RNAs termed miRNAs.
Some miRNAs have now been identified to be potent post-transcriptional regulators of lipid metabolism genes, including miR-122, miR-33, miR-758, and miR-106b.
Different strategies have been developed to modulate miRNA effects for therapeutic purposes.
The promise demonstrated by the use of anti-miRs in human preclinical studies, in the case of miR-122, raises the possibility that miR-33, miR-758, and miR-106b may become viable therapeutic targets in future.
This review summarizes the evidence for a critical role of some miRNAs in regulating cholesterol metabolism and suggests novel ways to manage dyslipidemias and cardiovascular diseases.
American Psychological Association (APA)
Rotllan, Noemi& Fernández-Hernando, Carlos. 2012. MicroRNA Regulation of Cholesterol Metabolism. Cholesterol،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502996
Modern Language Association (MLA)
Rotllan, Noemi& Fernández-Hernando, Carlos. MicroRNA Regulation of Cholesterol Metabolism. Cholesterol No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502996
American Medical Association (AMA)
Rotllan, Noemi& Fernández-Hernando, Carlos. MicroRNA Regulation of Cholesterol Metabolism. Cholesterol. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502996