Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The petroleum ether, chloroform, methanol, and aqueous extracts of Heliotropium indicum Linn.
(Family: Boraginaceae) were separately evaluated for their wound healing activity in rats using excision (normal and infected), incision, and dead space wound models.
The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound breaking strength, weights of the granulation tissue, determination of hydroxyproline, super oxide dismutase (SOD), catalase, and histopathology of the granulation tissues.
Nitrofurazone (0.2% w/w) in simple ointment I.
P.
was used as reference standard for the activity comparison.
The results revealed significant promotion of wound healing with both methanol and aqueous extracts with more promising activity with the methanol extract compared to other extracts under study.
In the wound infection model (with S.
aureus and P.
aeruginosa), the methanol extract showed significant healing activity similar to the reference standard nitrofurazone.
Significant increase in the granulation tissue weight, increased hydroxyproline content, and increased activity of SOD and catalase level with the animals treated with methanol extract in dead space wound model further augmented the wound healing potential of H.
indicum.
The present work substantiates its validity of the folklore use.
American Psychological Association (APA)
Dash, G. K.& Murthy, P. N.. 2011. Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats. ISRN Pharmacology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503008
Modern Language Association (MLA)
Dash, G. K.& Murthy, P. N.. Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats. ISRN Pharmacology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-503008
American Medical Association (AMA)
Dash, G. K.& Murthy, P. N.. Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats. ISRN Pharmacology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503008