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Identification of HLA-A24-Restricted Novel T Cell Epitope Peptides Derived from P-Cadherin and Kinesin Family Member 20A
Joint Authors
Yoshimura, Sachiko
Miyazawa, Motoki
Watanabe, Tomohisa
Tsunoda, Takuya
Nakamura, Yusuke
Yamaue, Hiroki
Osawa, Ryuji
Tani, Masaji
Nakagawa, Hidewaki
Takeda, Kazuyoshi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We here identified human leukocyte antigen-(HLA-)A∗2402-restricted epitope peptides from Cadherin 3, type 1, P-cadherin (CDH3) and kinesin family member 20A (KIF20A) that were found to be specifically expressed in cancer cells through genome-wide expression profile analysis.
CDH3-10-807 peptide and KIF20A-10-66 peptide successfully induced specific CTL clones, and these selectively responded to COS7 cells expressing both HLA-A∗2402 and respective protein while did not respond to parental cells or COS7 cells expressing either HLA-A∗2402 or respective protein.
Furthermore, CTL clones responded to cancer cells that endogenously express HLA-A∗2402 and respective protein, suggesting that CDH3-10-807 peptide and KIF20A-10-66 peptide are naturally presented on HLA-A∗2402 molecule of human cancer cells.
Our results demonstrated that CDH3-10-807 peptide and KIF20A-10-66 peptide are novel HLA-A24-restricted tumor-associated antigens and would be applicable for CTL-inducing cancer therapies.
American Psychological Association (APA)
Osawa, Ryuji& Tsunoda, Takuya& Yoshimura, Sachiko& Watanabe, Tomohisa& Miyazawa, Motoki& Tani, Masaji…[et al.]. 2012. Identification of HLA-A24-Restricted Novel T Cell Epitope Peptides Derived from P-Cadherin and Kinesin Family Member 20A. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503012
Modern Language Association (MLA)
Osawa, Ryuji…[et al.]. Identification of HLA-A24-Restricted Novel T Cell Epitope Peptides Derived from P-Cadherin and Kinesin Family Member 20A. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-503012
American Medical Association (AMA)
Osawa, Ryuji& Tsunoda, Takuya& Yoshimura, Sachiko& Watanabe, Tomohisa& Miyazawa, Motoki& Tani, Masaji…[et al.]. Identification of HLA-A24-Restricted Novel T Cell Epitope Peptides Derived from P-Cadherin and Kinesin Family Member 20A. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503012