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The Role of the Keap1Nrf2 Pathway in the Cellular Response to Methylmercury
Joint Authors
Kumagai, Yoshito
Toyama, Takashi
Shinkai, Yasuhiro
Kanda, Hironori
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Methylmercury (MeHg) is an environmental electrophile that covalently modifies cellular proteins with reactive thiols, resulting in the formation of protein adducts.
While such protein modifications, referred to as S-mercuration, are thought to be associated with the enzyme dysfunction and cellular damage caused by MeHg exposure, the current consensus is that (1) there is a cellular response to MeHg through the activation of NF-E2-related factor 2 (Nrf2) coupled to S-mercuration of its negative regulator, Kelch-like ECH-associated protein 1 (Keap1), and (2) the Keap1/Nrf2 pathway protects against MeHg toxicity.
In this review, we introduce our findings and discuss the observations of other workers concerning the S-mercuration of cellular proteins by MeHg and the importance of the Keap1/Nrf2 pathway in protection against MeHg toxicity in cultured cells and mice.
American Psychological Association (APA)
Kumagai, Yoshito& Kanda, Hironori& Shinkai, Yasuhiro& Toyama, Takashi. 2013. The Role of the Keap1Nrf2 Pathway in the Cellular Response to Methylmercury. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503031
Modern Language Association (MLA)
Kumagai, Yoshito…[et al.]. The Role of the Keap1Nrf2 Pathway in the Cellular Response to Methylmercury. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-503031
American Medical Association (AMA)
Kumagai, Yoshito& Kanda, Hironori& Shinkai, Yasuhiro& Toyama, Takashi. The Role of the Keap1Nrf2 Pathway in the Cellular Response to Methylmercury. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503031