The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy
Joint Authors
Shuhong, Zhou
Bo, Cui
Bingyin, Shi
Hongjun, Lv
Li, Xu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure.
This study was performed to determine the effect of Dantonic Pill (DP) treatment on β-catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control.
Including an analysis of the general metabolic index and renal function, immunohistochemical staining and reverse transcription real-time PCR for β-catenin were performed in the renal cortex of the rat models every 4 weeks.
After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β-catenin was not downregulated in the renal cortex.
The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β-catenin in rats with STZ-induced early-stage diabetic damage.
American Psychological Association (APA)
Shuhong, Zhou& Hongjun, Lv& Bo, Cui& Li, Xu& Bingyin, Shi. 2013. The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503064
Modern Language Association (MLA)
Shuhong, Zhou…[et al.]. The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-503064
American Medical Association (AMA)
Shuhong, Zhou& Hongjun, Lv& Bo, Cui& Li, Xu& Bingyin, Shi. The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503064