Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms
Joint Authors
Calzado, Enrique Rengifo
Cedeño, Mercedes
Carr, Adriana
Rengifo, Charles E.
Blanco, Rancés
Frómeta, Milagros
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The evaluation of 14F7 Mab (anti-N-glycolyl GM3 ganglioside) immunorecognition in normal skin, cutaneous malignant melanoma (CMM), and in lymph node metastases (LNM) has been previously reported.
In this work we extended the study to benign (BMN) and dysplastic (DMN) melanocytic nevi, basal (BCC), and squamous cell carcinoma (SCC).
Immunohistochemical assays with 14F7 followed by a biotinylated link universal and streptavidin-AP in normal and pathological tissues were made.
No reaction of 14F7 in normal skin (0/10) as well as a low reactivity in BMN (2/11) and DMN (1/7) was detected.
A limited staining in BCC (2/13) and in SCC (4/8) was also evidenced, while 14F7 Mab were mostly reactive in CMM (28/28) and in LNM (6/7).
These results suggest that 14F7 reactivity could be closely related with the more aggressive biological behavior of CMM and also support the use of NeuGcGM3 as target for both passive and active melanoma immunotherapy.
American Psychological Association (APA)
Blanco, Rancés& Calzado, Enrique Rengifo& Rengifo, Charles E.& Cedeño, Mercedes& Frómeta, Milagros& Carr, Adriana. 2011. Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms. ISRN Dermatology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503072
Modern Language Association (MLA)
Blanco, Rancés…[et al.]. Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms. ISRN Dermatology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-503072
American Medical Association (AMA)
Blanco, Rancés& Calzado, Enrique Rengifo& Rengifo, Charles E.& Cedeño, Mercedes& Frómeta, Milagros& Carr, Adriana. Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms. ISRN Dermatology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503072