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Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats
Joint Authors
Oztosun, Muzaffer
Korkmaz, Ahmet
Ay, Hakan
Simsek, Kemal
Oter, Sukru
Demirbas, Seref
Yildirim, Ali Osman
Sadir, Serdar
Ozler, Mehmet
Yildiz, Senol
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Hyperbaric oxygen (HBO2) exposure affects both oxidative and antioxidant systems.
This effect is positively correlated with the exposure time and duration of the treatment.
The present study aims enlightening the relation of HBO2 with oxidative/antioxidant systems when administered in a prolonged and repetitive manner in brain tissues of rats.
Sixty rats were divided into 6 study (n=8 for each) and 1 control (n=12) group.
Rats in the study groups were daily exposed 90-min HBO2 sessions at 2.8 ATA for 5, 10, 15, 20, 30 and 40 days.
One day after the last session, animals were sacrificed; their whole brain tissue was harvested and dissected into three different regions as the outer grey matter (cortex), the inner white matter and cerebellum.
Levels of lipid peroxidation and protein oxidation and activities of superoxide dismutase and glutathione peroxidase were measured in these tissues.
Malondialdehyde, carbonylated protein and glutathione peroxidase levels were found to be insignificantly increased at different time-points in the cerebral cortex, inner white matter and cerebellum, respectively.
These comparable results provide evidence for the safety of HBO treatments and/or successful adaptive mechanisms at least in the brain tissue of rats, even when administered for longer periods.
American Psychological Association (APA)
Simsek, Kemal& Ozler, Mehmet& Yildirim, Ali Osman& Sadir, Serdar& Demirbas, Seref& Oztosun, Muzaffer…[et al.]. 2012. Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-503097
Modern Language Association (MLA)
Simsek, Kemal…[et al.]. Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-503097
American Medical Association (AMA)
Simsek, Kemal& Ozler, Mehmet& Yildirim, Ali Osman& Sadir, Serdar& Demirbas, Seref& Oztosun, Muzaffer…[et al.]. Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-503097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503097