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Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress
Joint Authors
Wang, Leilei
Zhou, Yan
Wang, Meng
He, Qinghua
Zhang, Zheng
Guo, Lixin
Zhang, Lina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We analysed endothelial function and oxidative stress in patients with abnormal glucose metabolism, the effect of glucose load, and the impact of nateglinide.
109 participants were grouped into newly diagnosed diabetes, prediabetes, and control.
Fasting plasma glucose (FPG), postprandial plasma glucose (PPG), glycosylated haemoglobin (HbA1c), and glycated albumin (GA) varied significantly among the study groups (P<0.01).
Nitric oxide (NO) and insulin resistance index (HOMA-IRI) levels were markedly different between the newly diagnosed diabetes and the control (P<0.01).
Glucose loading lowered flow-mediated endothelium-dependent dilation (FMEDD), NO, and superoxide dismutase (SOD) (P<0.01).
Fasting and glucose loading FMEDD, FPG, PPG, HbA1c, and GA were negatively correlated (r=-0.4573, −0.4602, −0.3895, −0.3897, and r=-0.4594, −0.4803, −0.4494, −0.3885; P<0.01), whereas NO, SOD, and HOMA-β were positively correlated (r=0.2983, 0.3211, 0.311, and r=0.1954, 0.361, 0.2569; P<0.05).
After the treatment with nateglinide, significant decreases in FPG, PPG, GA, HbA1C, endothelin-1(ET-1), malondialdehyde (MDA), and HOMA-IRI were observed, whereas FMEDD, NO, and SOD increased (P<0.01).
Thus, the study demonstrated the adverse effect of glucose load on endothelial function and oxidative stress.
Nateglinide lowers blood glucose, reduces insulin resistance and oxidative stress, and improves endothelial function in newly diagnosed diabetes.
American Psychological Association (APA)
Wang, Leilei& Guo, Lixin& Zhang, Lina& Zhou, Yan& He, Qinghua& Zhang, Zheng…[et al.]. 2013. Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503106
Modern Language Association (MLA)
Wang, Leilei…[et al.]. Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-503106
American Medical Association (AMA)
Wang, Leilei& Guo, Lixin& Zhang, Lina& Zhou, Yan& He, Qinghua& Zhang, Zheng…[et al.]. Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503106