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Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression : A Pilot Study
Joint Authors
Tuunainen, Arja
Kalska, Hely
Lipsanen, Jari
Niemi-Pynttäri, Jussi
Stenberg, Jan-Henry
Lehikoinen, Sanna
Pesonen, Ullamari
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Depression has been shown to be associated with cognitive deficits in various cognitive domains.
However, it is still unclear which factors contribute to cognitive impairment.
The objective of this study was to find out whether a functional polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) gene is associated with the impairment of cognitive functioning among depressed patients.
In a pilot study, a sample of 19 patients with major depressive disorder (MDD) and 19 healthy controls was investigated with an extensive psychiatric and neuropsychological examination.
All participants were genotyped for 5-HTTLPR.
Depressed patients with the short allele of the 5-HTT promoter region exhibited inferior cognitive performance compared to patients with the long allele polymorphism.
In healthy controls, no association between genotype and cognitive performance was found.
The result suggests that in MDD patients with the short allele of the 5-HTTLPR polymorphism the vulnerability to cognitive impairment is increased compared to MDD patients without the short allele inheritance.
These preliminary findings need to be confirmed in a larger cohort of MDD patients.
American Psychological Association (APA)
Kalska, Hely& Pesonen, Ullamari& Lehikoinen, Sanna& Stenberg, Jan-Henry& Lipsanen, Jari& Niemi-Pynttäri, Jussi…[et al.]. 2012. Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression : A Pilot Study. Psychiatry Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503113
Modern Language Association (MLA)
Kalska, Hely…[et al.]. Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression : A Pilot Study. Psychiatry Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-503113
American Medical Association (AMA)
Kalska, Hely& Pesonen, Ullamari& Lehikoinen, Sanna& Stenberg, Jan-Henry& Lipsanen, Jari& Niemi-Pynttäri, Jussi…[et al.]. Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression : A Pilot Study. Psychiatry Journal. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503113