Relationship between Serum Transforming Growth Factor β1 Concentrations and the Duration of Type 1 Diabetes Mellitus in Children and Adolescents
Joint Authors
Rachoń, Dominik
Wiśniewski, Piotr
Raczynska, Dorota
Raczyńska, Krystyna
Myśliwiec, Małgorzata
Malinowska, Ewa
Zorena, Katarzyna
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to evaluate the relationship between serum transforming growth factor β1 (TGF-β1) concentrations and the duration of type 1 diabetes mellitus (T1DM) in children and adolescents.
One hundred and sixteen patients with T1DM and 19 healthy controls were examined.
Serum TGF-β1 concentrations were measured using the cytometric bead array (CBA).
A positive association between the time of diabetes duration and higher serum TGF-β1 concentrations was observed.
Similarly, the prevalence of microvascular complications, such as retinopathy and nephropathy, increased with the duration of diabetes.
Logistic regression analysis showed that serum TGF-β1 concentrations and the duration of the disease are independent risk factors of microangiopathy development.
Higher serum TGF-β1 concentrations were associated with a significant risk of microangiopathy development after 10 years of T1DM duration.
In the successive years of the disease, the effect was even stronger.
The results of our study indicate that serum TGF-β1 concentrations are one of the factors that may have an impact on the progression of vascular complications in children and adolescents with T1DM.
American Psychological Association (APA)
Zorena, Katarzyna& Raczynska, Dorota& Wiśniewski, Piotr& Malinowska, Ewa& Myśliwiec, Małgorzata& Raczyńska, Krystyna…[et al.]. 2013. Relationship between Serum Transforming Growth Factor β1 Concentrations and the Duration of Type 1 Diabetes Mellitus in Children and Adolescents. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503126
Modern Language Association (MLA)
Zorena, Katarzyna…[et al.]. Relationship between Serum Transforming Growth Factor β1 Concentrations and the Duration of Type 1 Diabetes Mellitus in Children and Adolescents. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-503126
American Medical Association (AMA)
Zorena, Katarzyna& Raczynska, Dorota& Wiśniewski, Piotr& Malinowska, Ewa& Myśliwiec, Małgorzata& Raczyńska, Krystyna…[et al.]. Relationship between Serum Transforming Growth Factor β1 Concentrations and the Duration of Type 1 Diabetes Mellitus in Children and Adolescents. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503126