Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders
Author
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The conserved noncoding microRNAs (miRNAs) that function to regulate gene expression are essential for the development and function of the brain and heart.
Changes in miRNA expression profiles are associated with an increased risk for developing neurodegenerative disorders as well as heart failure.
Here, the hypothesis of how miRNA-regulated pathways could contribute to comorbid neurological and cardiovascular disorders will be discussed.
Presentation.
Changes in miRNA expression occurring in the brain and heart could have an impact on coexisting neurological and cardiovascular characteristics by (1) modulating organ function, (2) accentuating cellular stress, and (3) impinging on neuronal and/or heart cell survival.
Testing.
Evaluation of miRNA expression profiles in the brain and heart tissues from individuals with comorbid neurodegenerative and cardiovascular disorders will be of great importance and relevance.
Implications.
Careful experimental design will shed light to the deeper understanding of the molecular mechanisms tying up those different but yet somehow connected diseases.
American Psychological Association (APA)
Hébert, Sébastien S.. 2009. Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-503136
Modern Language Association (MLA)
Hébert, Sébastien S.. Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-503136
American Medical Association (AMA)
Hébert, Sébastien S.. Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-503136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503136