PPARγ2Pro12Ala Polymorphism and Human Health
Author
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPARγ) is an important transcription factor regulating adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity.
Numerous genetic mutations of PPARγ have been identified and these mutations positively or negatively regulate insulin sensitivity.
Among these, a relatively common polymorphism of PPARγ, Pro12Ala of PPARγ2, the isoform expressed only in adipose tissue has been shown to be associated with lower body mass index, enhanced insulin sensitivity, and resistance to the risk of type 2 diabetes in human subjects carrying this mutation.
Subsequent studies in different ethnic populations, however, have revealed conflicting results, suggesting a complex interaction between the PPARγ2 Pro12Ala polymorphism and environmental factors such as the ratio of dietary unsaturated fatty acids to saturated fatty acids and/or between the PPARγ2 Pro12Ala polymorphism and genetic factors such as polymorphic mutations in other genes.
In addition, this polymorphic mutation in PPARγ2 is associated with other aspects of human diseases, including cancers, polycystic ovary syndrome, Alzheimer disease and aging.
This review will highlight findings from recent studies.
American Psychological Association (APA)
He, Weimin. 2009. PPARγ2Pro12Ala Polymorphism and Human Health. PPAR Research،Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-503138
Modern Language Association (MLA)
He, Weimin. PPARγ2Pro12Ala Polymorphism and Human Health. PPAR Research No. 2009 (2009), pp.1-15.
https://search.emarefa.net/detail/BIM-503138
American Medical Association (AMA)
He, Weimin. PPARγ2Pro12Ala Polymorphism and Human Health. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-503138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503138