Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling : Impact on the Aging Process
Joint Authors
Kauppinen, Anu
Salminen, Antero
Hyttinen, Juha M. T.
Kaarniranta, Kai
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The NF-κB signaling system and the autophagic degradation pathway are crucial cellular survival mechanisms, both being well conserved during evolution.
Emerging studies have indicated that the IKK/NF-κB signaling axis regulates autophagy in a context-dependent manner.
IKK complex and NF-κB can enhance the expression of Beclin 1 and other autophagy-related proteins and stimulate autophagy whereas as a feedback response, autophagy can degrade IKK components.
Moreover, NF-κB signaling activates the expression of autophagy inhibitors (e.g., A20 and Bcl-2/xL) and represses the activators of autophagy (BNIP3, JNK1, and ROS).
Several studies have indicated that NF-κB signaling is enhanced both during aging and cellular senescence, inducing a proinflammatory phenotype.
The aging process is also associated with a decline in autophagic degradation.
It seems that the activity of Beclin 1 initiation complex could be impaired with aging, since the expression of Beclin 1 decreases as does the activity of type III PI3K.
On the other hand, the expression of inhibitory Bcl-2/xL proteins increases with aging.
We will review the recent literature on the control mechanisms of autophagy through IKK/NF-κB signaling and emphasize that NF-κB signaling could be a potent repressor of autophagy with ageing.
American Psychological Association (APA)
Salminen, Antero& Hyttinen, Juha M. T.& Kauppinen, Anu& Kaarniranta, Kai. 2012. Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling : Impact on the Aging Process. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-503140
Modern Language Association (MLA)
Salminen, Antero…[et al.]. Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling : Impact on the Aging Process. International Journal of Cell Biology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-503140
American Medical Association (AMA)
Salminen, Antero& Hyttinen, Juha M. T.& Kauppinen, Anu& Kaarniranta, Kai. Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling : Impact on the Aging Process. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-503140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503140