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Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients
Joint Authors
Michelson, Georg
Struffert, Tobias
Waerntges, Simone
El-Rafei, Ahmed
Engelhorn, Tobias
Doerfler, Arnd
Otto, Marlen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Purpose of this study was to evaluate with diffusion-tensor imaging (DTI) changes of radial diffusivity (RD) and fractional anisotropy (FA) in the optic nerve (ON) and optic radiation (OR) in glaucoma and to determine whether changes in RD and FA correlate with disease severity.
Therefore, glaucoma patients and controls were examined using 3T.
Regions of interest were positioned on RD and FA maps, and mean values were calculated for ON and OR and correlated with optic nerve atrophy and reduced spatial-temporal contrast sensitivity (STCS) of the retina.
We found, that RD in glaucoma patients was significantly higher in the ON (0.74 ± 0.21 versus 0.58 ± 0.17⋅10−3 mm2 s−1; P<0.05) and OR (0.79 ± 0.23 versus 0.62 ± 0.14⋅10−3 mm2 s−1; P<0.05) compared to controls.
Aside, FA was significantly decreased (0.48 ± 0.15 versus 0.66 ± 0.12 and 0.50 ± 0.20 versus 0.66 ± 0.11; P<0.05).
Hereby, correlation between changes in RD/FA and optic nerve atrophy/STCS was observed (r>0.77).
In conclusion, DTI at 3 Tesla allows robust RD and FA measurements in the ON and OR.
Hereby, the extent of RD increase and FA decrease in glaucoma correlate with established ophthalmological examinations.
American Psychological Association (APA)
Engelhorn, Tobias& Michelson, Georg& Waerntges, Simone& Otto, Marlen& El-Rafei, Ahmed& Struffert, Tobias…[et al.]. 2012. Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503151
Modern Language Association (MLA)
Engelhorn, Tobias…[et al.]. Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-503151
American Medical Association (AMA)
Engelhorn, Tobias& Michelson, Georg& Waerntges, Simone& Otto, Marlen& El-Rafei, Ahmed& Struffert, Tobias…[et al.]. Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503151