Lupus Nephritis : An Overview of Recent Findings
Joint Authors
de Zubiria Salgado, Alberto
Herrera-Díaz, Catalina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis.
In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response.
IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation.
This leads to monocytes and polymorphonuclear cells chemotaxis.
Subsequent release of proteases generates endothelial injury and mesangial proliferation.
Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon.
This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes.
Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis.
Herein immunopathological findings of LN are reviewed.
American Psychological Association (APA)
de Zubiria Salgado, Alberto& Herrera-Díaz, Catalina. 2012. Lupus Nephritis : An Overview of Recent Findings. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-503155
Modern Language Association (MLA)
de Zubiria Salgado, Alberto& Herrera-Díaz, Catalina. Lupus Nephritis : An Overview of Recent Findings. Autoimmune Diseases No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-503155
American Medical Association (AMA)
de Zubiria Salgado, Alberto& Herrera-Díaz, Catalina. Lupus Nephritis : An Overview of Recent Findings. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-503155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503155