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Chronic Granulomatous Herpes Encephalitis in a Child with Clinically Intractable Epilepsy
Joint Authors
Kankirawatana, Pongkiat
Palmer, Cheryl Ann
Hackney, James R.
Kankirawatana, Suthida
Harrison, D. Keith
Rozzelle, Curtis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Most patients with herpes simplex virus Type I encephalitis experience an acute, monophasic illness.
Chronic encephalitis is much less common, and few late relapses are associated with intractable seizure disorders.
A 10-year-old boy was admitted to our institution for intractable epilepsy as part of an evaluation for epilepsy surgery.
His history was significant for herpes meningitis at age 4 months.
At that time, he presented to an outside hospital with fever for three days, with acyclovir treatment beginning on day 4 of his 40-day hospital course.
He later developed infantile spasms and ultimately a mixed seizure disorder.
Video electroencephalogram showed a Lennox-Gastaut-type pattern with frequent right frontotemporal spikes.
Imaging studies showed an abnormality in the right frontal operculum.
Based on these findings, he underwent a right frontal lobectomy.
Neuropathology demonstrated chronic granulomatous inflammation with focal necrosis and mineralizations.
Scattered lymphocytes, microglial nodules and nonnecrotizing granulomas were present with multinucleated giant cells.
Immunohistochemistry for herpes simplex virus showed focal immunoreactivity.
After undergoing acyclovir therapy, he returned to baseline with decreased seizure frequency.
This rare form of herpes encephalitis has only been reported in children, but the initial presentation of meningitis and the approximate 10-year-time interval in this case are unusual.
American Psychological Association (APA)
Hackney, James R.& Harrison, D. Keith& Rozzelle, Curtis& Kankirawatana, Suthida& Kankirawatana, Pongkiat& Palmer, Cheryl Ann. 2012. Chronic Granulomatous Herpes Encephalitis in a Child with Clinically Intractable Epilepsy. Case Reports in Pediatrics،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-503170
Modern Language Association (MLA)
Hackney, James R.…[et al.]. Chronic Granulomatous Herpes Encephalitis in a Child with Clinically Intractable Epilepsy. Case Reports in Pediatrics No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-503170
American Medical Association (AMA)
Hackney, James R.& Harrison, D. Keith& Rozzelle, Curtis& Kankirawatana, Suthida& Kankirawatana, Pongkiat& Palmer, Cheryl Ann. Chronic Granulomatous Herpes Encephalitis in a Child with Clinically Intractable Epilepsy. Case Reports in Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-503170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503170