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Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma
Joint Authors
Dombrowski, Frank
Calvisi, Diego F.
Evert, Matthias
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Hepatocellular carcinoma (HCC) is one of the most frequent solid tumors worldwide, with limited treatment options and a dismal prognosis.
Thus, there is a strong need to expand the basic and translational research on this deadly disease in order to improve the prognosis of HCC patients.
Although the etiologic factors responsible for HCC development have been identified, the molecular pathogenesis of liver cancer remains poorly understood.
Recent evidence has shown the frequent downregulation of Ras association domain family (RASSF) proteins both in the early and late stages of hepatocarcinogenesis.
Here, we summarize the data available on the pathogenetic role of inactivation of RASSF proteins in liver cancer, the molecular mechanisms responsible for suppression of RASSF proteins in HCC, and the possible clinical implications arising from these discoveries.
Altogether, the data indicate that inactivation of the RASSF1A tumor suppressor is ubiquitous in human liver cancer, while downregulation of RASSF2 and RASSF5 proteins is limited to specific HCC subsets.
Also, the present findings speak in favour of therapeutic strategies aimed at reexpressing RASSF1A, RASSF2, and RASSF5 genes and/or inactivating the RASSF cellular inhibitors for the treatment of human liver cancer.
American Psychological Association (APA)
Calvisi, Diego F.& Evert, Matthias& Dombrowski, Frank. 2012. Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma. Molecular Biology International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503176
Modern Language Association (MLA)
Calvisi, Diego F.…[et al.]. Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma. Molecular Biology International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-503176
American Medical Association (AMA)
Calvisi, Diego F.& Evert, Matthias& Dombrowski, Frank. Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503176