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A Mathematical Model of Immune-System-Melanoma Competition
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We present a mathematical model developed to reproduce the immune response entitled with the combined administration of activated OT1 cytotoxic T lymphocytes (CTLs) and Anti-CD137 monoclonal antibodies.
The treatment is directed against melanoma in B16 OVA mouse models exposed to a specific immunotherapy strategy.
We model two compartments: the injection point compartment where the treatment is administered and the skin compartment where melanoma tumor cells proliferate.
To model the migration of OT1 CTLs and antibodies from the injection to the skin compartment, we use delay differential equations (DDEs).
The outcomes of the mathematical model are in good agreement with the in vivo results.
Moreover, sensitivity analysis of the mathematical model underlines the key role of OT1 CTLs and suggests that a possible reduction of the number of injected antibodies should not affect substantially the treatment efficacy.
American Psychological Association (APA)
Pennisi, Marzio. 2012. A Mathematical Model of Immune-System-Melanoma Competition. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-503252
Modern Language Association (MLA)
Pennisi, Marzio. A Mathematical Model of Immune-System-Melanoma Competition. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-503252
American Medical Association (AMA)
Pennisi, Marzio. A Mathematical Model of Immune-System-Melanoma Competition. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-503252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503252