Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine
Joint Authors
Zampa, Maysa F.
Zucolotto, Valtencir
Araújo, Inês Maria de S.
dos Santos Júnior, José Ribeiro
Eiras, Carla
Leite, José Roberto de S. A.
Source
International Journal of Analytical Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The antimicrobial peptide dermaseptin 01 (DS 01), from the skin secretion of Phyllomedusa hypochondrialis frogs, was immobilized in nanostructured layered films in conjunction with nickel tetrasulfonated phthalocyanines (NiTsPc), widely used in electronic devices, using layer-by-layer technique.
The films were used as a biosensor to detect the presence of dopamine (DA), a neurotransmitter associated with diseases such as Alzheimer's and Parkinson's, with detection limits in the order of 10−6 mol L−1.
The use of DS 01 in LbL film generated selectivity in the detection of DA despite the presence of ascorbic acid found in biological fluids.
This work is the first to report that the antimicrobial peptide and NiTsPc LbL film exhibits electroanalytical activity to DA oxidation.
The selectivity in the detection of DA is a fundamental aspect for the development of electrochemical sensors with potential applications in the biomedical and pharmaceutical industries.
American Psychological Association (APA)
Zampa, Maysa F.& Araújo, Inês Maria de S.& dos Santos Júnior, José Ribeiro& Zucolotto, Valtencir& Leite, José Roberto de S. A.& Eiras, Carla. 2012. Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine. International Journal of Analytical Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-503271
Modern Language Association (MLA)
Zampa, Maysa F.…[et al.]. Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine. International Journal of Analytical Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-503271
American Medical Association (AMA)
Zampa, Maysa F.& Araújo, Inês Maria de S.& dos Santos Júnior, José Ribeiro& Zucolotto, Valtencir& Leite, José Roberto de S. A.& Eiras, Carla. Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine. International Journal of Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-503271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503271