Immunohistochemical Expression of Platelet-Derived Growth Factor Receptors in Ovarian Cancer Patients with Long-Term Follow-Up
Joint Authors
Dahl Steffensen, Karina
Madsen, Christine Vestergaard
Jakobsen, Anders
Waldstrøm, Marianne
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
The well-documented role of the PDGF system in tumor growth and angiogenesis has prompted the development of new biological agents targeting the PDGF system.
The aim of the present study was to analyze the expression of the PDGF-receptors in ovarian cancer and to investigate its relation to histopathological parameters and long-term overall survival.
Methods.
The immunohistochemical expression of PDGFR-α and PDGFR-β was investigated in tumor and stromal cells in 170 patients with histologically verified epithelial ovarian cancer.
Results.
Almost half of the tumor specimens showed high expression of PDGFR-α and PDGFR-β in tumor cells (43% and 41%) and in stromal compartments (32% and 44%).
There was a significant association between high expression of PDGFR-α and high expression of PDGFR-β in both tumor and stromal cells.
Coexpression of PDGFR-α and PDGFR-β in stromal cells was seen more often in serous adenocarcinomas than in nonserous adenocarcinomas.
No clear correlation between PDGFR expression and longterm overall survival or clinical parameters was found.
Conclusions.
PDGFR-α and PDGFR-β were expressed in a subset of ovarian carcinomas but did not show significant prognostic importance in this material.
American Psychological Association (APA)
Madsen, Christine Vestergaard& Dahl Steffensen, Karina& Waldstrøm, Marianne& Jakobsen, Anders. 2012. Immunohistochemical Expression of Platelet-Derived Growth Factor Receptors in Ovarian Cancer Patients with Long-Term Follow-Up. Pathology Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503310
Modern Language Association (MLA)
Madsen, Christine Vestergaard…[et al.]. Immunohistochemical Expression of Platelet-Derived Growth Factor Receptors in Ovarian Cancer Patients with Long-Term Follow-Up. Pathology Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-503310
American Medical Association (AMA)
Madsen, Christine Vestergaard& Dahl Steffensen, Karina& Waldstrøm, Marianne& Jakobsen, Anders. Immunohistochemical Expression of Platelet-Derived Growth Factor Receptors in Ovarian Cancer Patients with Long-Term Follow-Up. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503310