The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
Joint Authors
Kilic, E.
Demiroglu-Zergeroglu, A.
Yanikkaya-Demirel, G.
Basara-Cigerim, B.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis.
In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines.
Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner.
Additionally, the combination of QU + CIS was found more effective when compared with individual treatment of agents.
American Psychological Association (APA)
Demiroglu-Zergeroglu, A.& Basara-Cigerim, B.& Kilic, E.& Yanikkaya-Demirel, G.. 2010. The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-503324
Modern Language Association (MLA)
Demiroglu-Zergeroglu, A.…[et al.]. The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-503324
American Medical Association (AMA)
Demiroglu-Zergeroglu, A.& Basara-Cigerim, B.& Kilic, E.& Yanikkaya-Demirel, G.. The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-503324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503324
