In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologically modulated.
Both high-throughput chemical screening and facile detection of blood-cell-related phenotypes are feasible in embryonic/larval zebrafish.
Two recent studies utilizing phenotypic chemical screens in zebrafish have identified several compounds that promote hematopoietic stem cell formation and reverse the hematopoietic phenotypes of a leukemia oncogene, respectively.
These studies illustrate efficient drug discovery processes in zebrafish and reveal novel biological roles of prostaglandin E2 in hematopoietic and leukemia stem cells.
Furthermore, the compounds discovered in zebrafish screens have become promising therapeutic candidates against leukemia and included in a clinical trial for enhancing hematopoietic stem cells during hematopoietic cell transplantation.
American Psychological Association (APA)
Zhang, Yiyun& Yeh, J.-R. Joanna. 2012. In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases. Advances in Hematology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503334
Modern Language Association (MLA)
Zhang, Yiyun& Yeh, J.-R. Joanna. In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases. Advances in Hematology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-503334
American Medical Association (AMA)
Zhang, Yiyun& Yeh, J.-R. Joanna. In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503334