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Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose : Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism
Joint Authors
Mels, Catharina M. C.
van der Westhuizen, Francois H.
Pretorius, Pieter J.
Erasmus, Elardus
Jansen van Rensburg, Peet
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Acetylsalicylic acid and/or its metabolites are implicated to have various effects on metabolism and, especially, on mitochondrial function.
These effects include both inhibitory and stimulatory effects.
We investigated the effect of both combined and separate oral acetylsalicylic acid and acetaminophen administration at therapeutic doses on the urinary metabolite profile of human subjects.
In this paper, we provided in vivo evidence, in human subjects, of a statistically significant increase in isobutyrylcarnitine after the administration of a therapeutic dose of acetylsalicylic acid.
We, therefore, propose an inhibitory effect of acetylsalicylic acid on the short-chain fatty acid metabolism, possibly at the level of isobutyryl-CoA dehydrogenase.
American Psychological Association (APA)
Mels, Catharina M. C.& Jansen van Rensburg, Peet& van der Westhuizen, Francois H.& Pretorius, Pieter J.& Erasmus, Elardus. 2011. Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose : Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism. ISRN Pharmacology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503357
Modern Language Association (MLA)
Mels, Catharina M. C.…[et al.]. Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose : Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism. ISRN Pharmacology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-503357
American Medical Association (AMA)
Mels, Catharina M. C.& Jansen van Rensburg, Peet& van der Westhuizen, Francois H.& Pretorius, Pieter J.& Erasmus, Elardus. Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose : Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism. ISRN Pharmacology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503357