The Effect of Superparamagnetic Iron Oxide with iRGD Peptide on the Labeling of Pancreatic Cancer Cells In Vitro : A Preliminary Study
Joint Authors
Liu, Gang
Chen, Tian Wu
Zhang, Xiao Ming
Zhu, Jiang
Zhang, Juan Juan
Pu, Yu
Yao, Wei Wu
Zuo, Hou Dong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The iRGD peptide loaded with iron oxide nanoparticles for tumor targeting and tissue penetration was developed for targeted tumor therapy and ultrasensitive MR imaging.
Binding of iRGD, a tumor homing peptide, is mediated by integrins, which are widely expressed on the surface of cells.
Several types of small molecular drugs and nanoparticles can be transfected into cells with the help of iRGD peptide.
Thus, we postulate that SPIO nanoparticles, which have good biocompatibility, can also be transfected into cells using iRGD.
Despite the many kinds of cell labeling studies that have been performed with SPIO nanoparticles and RGD peptide or its analogues, only a few have applied SPIO nanoparticles with iRGD peptide in pancreatic cancer cells.
This paper reports our preliminary findings regarding the effect of iRGD peptide (CRGDK/RGPD/EC) combined with SPIO on the labeling of pancreatic cancer cells.
The results suggest that SPIO with iRGD peptide can enhance the positive labeling rate of cells and the uptake of SPIO.
Optimal functionalization was achieved with the appropriate concentration or concentration range of SPIO and iRGD peptide.
This study describes a simple and economical protocol to label panc-1 cells using SPIO in combination with iRGD peptide and may provide a useful method to improve the sensitivity of pancreatic cancer imaging.
American Psychological Association (APA)
Zuo, Hou Dong& Yao, Wei Wu& Chen, Tian Wu& Zhu, Jiang& Zhang, Juan Juan& Pu, Yu…[et al.]. 2014. The Effect of Superparamagnetic Iron Oxide with iRGD Peptide on the Labeling of Pancreatic Cancer Cells In Vitro : A Preliminary Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503398
Modern Language Association (MLA)
Zuo, Hou Dong…[et al.]. The Effect of Superparamagnetic Iron Oxide with iRGD Peptide on the Labeling of Pancreatic Cancer Cells In Vitro : A Preliminary Study. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-503398
American Medical Association (AMA)
Zuo, Hou Dong& Yao, Wei Wu& Chen, Tian Wu& Zhu, Jiang& Zhang, Juan Juan& Pu, Yu…[et al.]. The Effect of Superparamagnetic Iron Oxide with iRGD Peptide on the Labeling of Pancreatic Cancer Cells In Vitro : A Preliminary Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503398