Cutting Edge PBPK Models and Analyses : Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms
Joint Authors
Krishnan, Kannan
Evans, Marina V.
Caldwell, Jane C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Physiologically based Pharmacokinetic (PBPK) models are used for predictions of internal or target dose from environmental and pharmacologic chemical exposures.
Their use in human risk assessment is dependent on the nature of databases (animal or human) used to develop and test them, and includes extrapolations across species, experimental paradigms, and determination of variability of response within human populations.
Integration of state-of-the science PBPK modeling with emerging computational toxicology models is critical for extrapolation between in vitro exposures, in vivo physiologic exposure, whole organism responses, and long-term health outcomes.
This special issue contains papers that can provide the basis for future modeling efforts and provide bridges to emerging toxicology paradigms.
In this overview paper, we present an overview of the field and introduction for these papers that includes discussions of model development, best practices, risk-assessment applications of PBPK models, and limitations and bridges of modeling approaches for future applications.
Specifically, issues addressed include: (a) increased understanding of human variability of pharmacokinetics and pharmacodynamics in the population, (b) exploration of mode of action hypotheses (MOA), (c) application of biological modeling in the risk assessment of individual chemicals and chemical mixtures, and (d) identification and discussion of uncertainties in the modeling process.
American Psychological Association (APA)
Caldwell, Jane C.& Evans, Marina V.& Krishnan, Kannan. 2012. Cutting Edge PBPK Models and Analyses : Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503399
Modern Language Association (MLA)
Caldwell, Jane C.…[et al.]. Cutting Edge PBPK Models and Analyses : Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms. Journal of Toxicology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-503399
American Medical Association (AMA)
Caldwell, Jane C.& Evans, Marina V.& Krishnan, Kannan. Cutting Edge PBPK Models and Analyses : Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503399