Melanoma inhibitory activity (MIA) and transforming growth factor-β (TGF-β) levels in the sera of juvenile arthritis
Other Title(s)
الفعالية المثبطة للميلانوما(MIA) ومستويات عامل النمو المتحول بيتا (TGF) في مصل مرضى التهاب المفاصل اليافعين .
Joint Authors
Rida, Mervat Abd al-Hamid
Husayn, Iman Abu Bakr
al-Husayni, Muna al-Jamal
Usama, Amani A.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 30, Issue 1 (31 Jan. 2003), pp.103-113, 11 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2003-01-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Aim of Study : We measured serum levels of MIA and TGF-β by means of ELISA and investigated whether they provide clinically relevant parameters in juvenile arthritis patients.
We also evaluated their correlations with clinical and laboratory parameters Methodology : Serum was obtained from 10 poly-articular juvenile arthritis (pa-JRA (patients, 10 childhood systemic lupus erythematosus (ch-SLE) patients, 10 childhood systemic sclerosis (ch-SSC) patients and 10 apparently healthy children as a control group.
Results : Both MIA and TGF-β serum concentrations were found to increase in both destructive (JRA) and non-destructive (ch-SLE and ch-SSc) juvenile arthritis.
We found no correlation with disease activity, clinical or laboratory parameters except RF.
Conclusion : MIA and TGF-β are not serum markers of a specific disease.
In addition, the presence of elevated MIA in the sera of juvenile arthritic patients very likely reflects passive release from necrotic or apoptotic chondrocytes and is partly due to chondrocyte activation.
This is supported by the fact that MIA level was only associated with RF positivity and not with markers of inflammation.
American Psychological Association (APA)
Rida, Mervat Abd al-Hamid& Husayn, Iman Abu Bakr& al-Husayni, Muna al-Jamal& Usama, Amani A.. 2003. Melanoma inhibitory activity (MIA) and transforming growth factor-β (TGF-β) levels in the sera of juvenile arthritis. Egyptian Rheumatology and Rehabilitation،Vol. 30, no. 1, pp.103-113.
https://search.emarefa.net/detail/BIM-50340
Modern Language Association (MLA)
Rida, Mervat Abd al-Hamid…[et al.]. Melanoma inhibitory activity (MIA) and transforming growth factor-β (TGF-β) levels in the sera of juvenile arthritis. Egyptian Rheumatology and Rehabilitation Vol. 30, no. 1 (Jan. 2003), pp.103-113.
https://search.emarefa.net/detail/BIM-50340
American Medical Association (AMA)
Rida, Mervat Abd al-Hamid& Husayn, Iman Abu Bakr& al-Husayni, Muna al-Jamal& Usama, Amani A.. Melanoma inhibitory activity (MIA) and transforming growth factor-β (TGF-β) levels in the sera of juvenile arthritis. Egyptian Rheumatology and Rehabilitation. 2003. Vol. 30, no. 1, pp.103-113.
https://search.emarefa.net/detail/BIM-50340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 111-113
Record ID
BIM-50340