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Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection
Joint Authors
Capria, A.
Di Daniele, Nicola
Franzese, Ornella
Mascali, A.
Paganizza, L.
Castagnola, V.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acute rejection (AR) is responsible for up to 12% of graft loss with the highest risk generally occurring during the first six months after transplantation.
AR may be broadly classified into humoral as well as cellular rejection.
Cellular rejection develops when donor alloantigens, presented by antigen-presenting cells (APCs) through class I or class II HLA molecules, activate the immune response against the allograft, resulting in activation of naive T cells that differentiate into subsets including cytotoxic CD8+ and helper CD4+ T cells type 1 (TH1) and TH2 cells or into cytoprotective immunoregulatory T cells (Tregs).
The immune reaction directed against a renal allograft has been suggested to be characterized by two major components: a destructive one, mediated by CD4+ helper and CD8+ cytotoxic T cells, and a protective response, mediated by Tregs.
The balance between these two opposite immune responses can significantly affect the graft survival.
Many studies have been performed in order to define the role of Tregs either in the immunodiagnosis of transplant rejection or as predictor of the clinical outcome.
However, information available from the literature shows a contradictory picture that deserves further investigation.
American Psychological Association (APA)
Franzese, Ornella& Mascali, A.& Capria, A.& Castagnola, V.& Paganizza, L.& Di Daniele, Nicola. 2013. Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-503402
Modern Language Association (MLA)
Franzese, Ornella…[et al.]. Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-503402
American Medical Association (AMA)
Franzese, Ornella& Mascali, A.& Capria, A.& Castagnola, V.& Paganizza, L.& Di Daniele, Nicola. Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-503402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503402