Directed Fiber Outgrowth from Transplanted Embryonic Cortex-Derived Neurospheres in the Adult Mouse Brain
Joint Authors
Radojevic, Vesna
Kapfhammer, Josef P.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neural transplantation has emerged as an attractive strategy for the replacement of neurons that have been lost in the central nervous system.
Multipotent neural progenitor cells are potentially useful as donor cells to repopulate the degenerated regions.
One important aspect of a transplantation strategy is whether transplanted cells are capable of fiber outgrowth with the aim of rebuilding axonal connections within the host brain.
To address this issue, we expanded neuronal progenitor from the cortex of embryonic day 15 ubiquitously green fluorescent protein-expressing transgenic mice as neurospheres in vitro and grafted them into the entorhinal cortex of 8-week-old mice immediately after a perforant pathway lesion.
After transplantation into a host brain with a lesion of the entorhino-hippocampal projection, the neurosphere-derived cells extended long fiber projections directed towards the dentate gyrus.
Our results indicate that transplantation of neurosphere-derived cells might be a promising strategy to replace lost or damaged axonal projections.
American Psychological Association (APA)
Radojevic, Vesna& Kapfhammer, Josef P.. 2010. Directed Fiber Outgrowth from Transplanted Embryonic Cortex-Derived Neurospheres in the Adult Mouse Brain. Neural Plasticity،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-503411
Modern Language Association (MLA)
Radojevic, Vesna& Kapfhammer, Josef P.. Directed Fiber Outgrowth from Transplanted Embryonic Cortex-Derived Neurospheres in the Adult Mouse Brain. Neural Plasticity No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-503411
American Medical Association (AMA)
Radojevic, Vesna& Kapfhammer, Josef P.. Directed Fiber Outgrowth from Transplanted Embryonic Cortex-Derived Neurospheres in the Adult Mouse Brain. Neural Plasticity. 2010. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-503411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503411