Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge
Joint Authors
Tanaka, Junichi
Hermawan, Idam
Trianto, Agus
Suzuka, Toshimasa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Marine sponges have been recognized as potentially rich sources of various bioactive molecules.
In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL.
Purification of the extract yielded two new macrolides 2 and 3 along with known candidaspongiolide (1).
The structures for compounds 2 and 3 were elucidated by spectral analysis (H1, C13, COSY, HMQC, HMBC) and by comparison of their NMR data with those of 1.
Compounds 2 and 3 exhibited a little more potent cytotoxicity (IC50 4.7 and 19 ng/mL) than that (IC50 37 ng/mL) of candidaspongiolide (1) against NBT-T2 cells.
American Psychological Association (APA)
Trianto, Agus& Hermawan, Idam& Suzuka, Toshimasa& Tanaka, Junichi. 2011. Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-503425
Modern Language Association (MLA)
Trianto, Agus…[et al.]. Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge. ISRN Pharmaceutics No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-503425
American Medical Association (AMA)
Trianto, Agus& Hermawan, Idam& Suzuka, Toshimasa& Tanaka, Junichi. Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-503425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503425