Diagnostic Performance of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Postchemotherapy Management of Patients with Seminoma : Systematic Review and Meta-Analysis
Joint Authors
Treglia, Giorgio
Sadeghi, Ramin
Giovanella, Luca
Bertagna, Francesco
Annunziata, Salvatore
Caldarella, Carmelo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To meta-analyze published data about the diagnostic performance of fluorine-18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) in the postchemotherapy management of patients with seminoma.
Methods.
A comprehensive literature search of studies published through January 2014 on this topic was performed.
All retrieved studies were reviewed and qualitatively analyzed.
Pooled sensitivity and specificity, positive and negative predictive values (PPV and NPV), accuracy, and area under the summary ROC curve (AUC) of 18F-FDG-PET or PET/CT on a per examination-based analysis were calculated.
Subgroup analyses considering the size of residual/recurrent lesions were carried out.
Results.
Nine studies including 375 scans were selected.
The pooled analysis provided the following results: sensitivity 78% (95% confidence interval (95% CI): 67–87%), specificity 86% (95% CI: 81–89%), PPV 58% (95% CI: 48–68%), NPV 94% (95% CI: 90–96%), and accuracy 84% (95% CI: 80–88%).
The AUC was 0.90.
A better diagnostic accuracy of 18F-FDG-PET or PET/CT in evaluating residual/recurrent lesions >3 cm compared to those <3 cm was found.
Conclusions.
18F-FDG-PET and PET/CT were demonstrated to be accurate imaging methods in the postchemotherapy management of patients with seminoma; nevertheless possible sources of false-negative and false-positive results should be considered.
The literature focusing on this setting still remains limited and cost-effectiveness analyses are warranted.
American Psychological Association (APA)
Treglia, Giorgio& Sadeghi, Ramin& Annunziata, Salvatore& Caldarella, Carmelo& Bertagna, Francesco& Giovanella, Luca. 2014. Diagnostic Performance of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Postchemotherapy Management of Patients with Seminoma : Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-503433
Modern Language Association (MLA)
Treglia, Giorgio…[et al.]. Diagnostic Performance of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Postchemotherapy Management of Patients with Seminoma : Systematic Review and Meta-Analysis. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-503433
American Medical Association (AMA)
Treglia, Giorgio& Sadeghi, Ramin& Annunziata, Salvatore& Caldarella, Carmelo& Bertagna, Francesco& Giovanella, Luca. Diagnostic Performance of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Postchemotherapy Management of Patients with Seminoma : Systematic Review and Meta-Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-503433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503433