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Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL6J Type 2 Diabetes Mouse Model
Joint Authors
Jayaraman, Selvaraj
Ramachandran, A. V.
Hardikar, Anandwardhan A.
Ansarullah,
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oreocnide integrifolia (OI) leaves are used as folklore medicine by the people of northeast India to alleviate diabetic symptoms.
Preliminary studies revealed hypoglycemic and hypolipidemic potentials of the aqueous leaf extract.
The present study was carried out to evaluate whether the OI extract induces insulin secretion in vivo and in vitro and also whether it is mediated through the insulin-signaling pathway.
The experimental set-up consisted of three groups of C57BL/6J mice strain: (i) control animals fed with standard laboratory diet, (ii) diabetic animals fed with a high-fat diet for 24 weeks and (iii) extract-supplemented animals fed with 3% OI extract along with high-fat diet for 24 weeks.
OI-extract supplementation lowered adiposity and plasma glucose and insulin levels.
Immunoblot analysis of IRS-1, Akt and Glut-4 protein expressions in muscles of extract-supplemented animals revealed that glucoregulation was mediated through the insulin-signaling pathway.
Moreover, immunostaining of pancreas revealed increased insulin immunopositive cells in OI-extract-treated animals.
In addition, the insulin secretogogue ability of the OI extract was demonstrated when challenged with high glucose concentration using isolated pancreatic islets in vitro.
Overall, the present study demonstrates the possible mechanism of glucoregulation of OI extract suggestive of its therapeutic potential for the management of diabetes mellitus.
American Psychological Association (APA)
Ansarullah, & Jayaraman, Selvaraj& Hardikar, Anandwardhan A.& Ramachandran, A. V.. 2011. Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL6J Type 2 Diabetes Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-503436
Modern Language Association (MLA)
Ansarullah,…[et al.]. Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL6J Type 2 Diabetes Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-503436
American Medical Association (AMA)
Ansarullah, & Jayaraman, Selvaraj& Hardikar, Anandwardhan A.& Ramachandran, A. V.. Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL6J Type 2 Diabetes Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-503436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503436