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Negative Symptoms of Psychosis Correlate with Gene Expression of the Wntβ-Catenin Signaling Pathway in Peripheral Blood
Joint Authors
Glatt, Stephen J.
Tsuang, Ming T.
Bousman, Chad A.
Chandler, Sharon D.
Everall, Ian P.
Kremen, William S.
Lohr, James
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Genes in the Wnt (wingless)/β-catenin signaling pathway have been implicated in schizophrenia pathogenesis.
No study has examined this pathway in the broader context of psychosis symptom severity.
We investigated the association between symptom severity scores and expression of 25 Wnt pathway genes in blood from 19 psychotic patients.
Significant correlations between negative symptom scores and deshivelled 2 (DVL2) (radj=−0.70; P=0.0008) and glycogen synthase kinase 3 beta (GSK3B) (radj=0.48; P=0.039) were observed.
No gene expression levels were associated with positive symptoms.
Our findings suggest that the Wnt signaling pathway may harbor biomarkers for severity of negative but not positive symptoms.
American Psychological Association (APA)
Bousman, Chad A.& Glatt, Stephen J.& Chandler, Sharon D.& Lohr, James& Kremen, William S.& Tsuang, Ming T.…[et al.]. 2013. Negative Symptoms of Psychosis Correlate with Gene Expression of the Wntβ-Catenin Signaling Pathway in Peripheral Blood. Psychiatry Journal،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-503458
Modern Language Association (MLA)
Bousman, Chad A.…[et al.]. Negative Symptoms of Psychosis Correlate with Gene Expression of the Wntβ-Catenin Signaling Pathway in Peripheral Blood. Psychiatry Journal No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-503458
American Medical Association (AMA)
Bousman, Chad A.& Glatt, Stephen J.& Chandler, Sharon D.& Lohr, James& Kremen, William S.& Tsuang, Ming T.…[et al.]. Negative Symptoms of Psychosis Correlate with Gene Expression of the Wntβ-Catenin Signaling Pathway in Peripheral Blood. Psychiatry Journal. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-503458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503458