Monoamine Oxidase A and B Gene Polymorphisms and Negative and Positive Symptoms in Schizophrenia
Joint Authors
Camarena, Beatriz
Aguilar, Alejandro
Nicolini, Humberto
Saracco, Ricardo
Palacios, Jorge
Fresán, Ana
Tovilla, Alfonso
Escamilla, Raúl
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Given that schizophrenia is a heterogeneous disorder, the analysis of clinical characteristics could help to identify homogeneous phenotypes that may be of relevance in genetic studies.
Linkage and association studies have suggested that a locus predisposing to schizophrenia may reside within Xp11.
We analyzed uVNTR and rs1137070, polymorphisms from MAOA and rs1799836 of MAOB genes to perform single SNP case-control association study in a sample of 344 schizophrenia patients and 124 control subjects.
Single polymorphism analysis of uVNTR, rs1137070 and rs1799836 SNPs did not show statistical differences between cases and controls.
Multivariate ANOVA analysis of clinical characteristics showed statistical differences between MAOB/rs1799836 and affective flattening scores (F=4.852, P=0.009), and significant association between MAOA/uVNTR and affective flattening in female schizophrenia patients (F=4.236, P=0.016) after Bonferroni’s correction.
Our preliminary findings could suggest that severity of affective flattening may be associated by modifier variants of MAOA and MAOB genes in female Mexican patients with schizophrenia.
However, further large-scale studies using quantitative symptom-based phenotypes and several candidate variants should be analyzed to obtain a final conclusion.
American Psychological Association (APA)
Camarena, Beatriz& Fresán, Ana& Aguilar, Alejandro& Escamilla, Raúl& Saracco, Ricardo& Palacios, Jorge…[et al.]. 2012. Monoamine Oxidase A and B Gene Polymorphisms and Negative and Positive Symptoms in Schizophrenia. ISRN Psychiatry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503461
Modern Language Association (MLA)
Camarena, Beatriz…[et al.]. Monoamine Oxidase A and B Gene Polymorphisms and Negative and Positive Symptoms in Schizophrenia. ISRN Psychiatry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-503461
American Medical Association (AMA)
Camarena, Beatriz& Fresán, Ana& Aguilar, Alejandro& Escamilla, Raúl& Saracco, Ricardo& Palacios, Jorge…[et al.]. Monoamine Oxidase A and B Gene Polymorphisms and Negative and Positive Symptoms in Schizophrenia. ISRN Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503461