Oxidative Stress and Inflammation : Essential Partners in Alcoholic Liver Disease
Joint Authors
Ambade, Aditya
Mandrekar, Pranoti
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation.
Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD.
The key mechanisms identified so far are sensitization to gut-derived endotoxin/lipopolysaccharide resulting in proinflammatory cytokine production and cellular stress due to oxidative processes, contributing to the development and progression of disease.
While oxidative stress and inflammatory responses are studied independently in ALD, mechanisms linking these two processes play a major role in pathogenesis of disease.
Here we review major players of oxidative stress and inflammation and highlight signaling intermediates regulated by oxidative stress that provokes proinflammatory responses in alcoholic liver disease.
American Psychological Association (APA)
Ambade, Aditya& Mandrekar, Pranoti. 2012. Oxidative Stress and Inflammation : Essential Partners in Alcoholic Liver Disease. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-503485
Modern Language Association (MLA)
Ambade, Aditya& Mandrekar, Pranoti. Oxidative Stress and Inflammation : Essential Partners in Alcoholic Liver Disease. International Journal of Hepatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-503485
American Medical Association (AMA)
Ambade, Aditya& Mandrekar, Pranoti. Oxidative Stress and Inflammation : Essential Partners in Alcoholic Liver Disease. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-503485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503485