The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice
Joint Authors
Lewicki, Sławomir
Skopińska-Różewska, Ewa
Stankiewicz, Wanda
Zdanowski, Robert
Niemcewicz, Marcin
Radomska-Leśniewska, Dorota M.
Kocik, Janusz
Skopiński, Piotr
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
PADMA 28 is a herbal multicompound remedy that originates from traditional Tibetan medicine and possesses anti-inflammatory, antioxidant, antimicrobial, angioprotecting, and wound healing properties.
The aim of the present study was to evaluate the influence of this remedy on immunological angiogenesis and granulocytes metabolic activity in Balb/c mice.
Mice were fed daily, for seven days, with 5.8 mg of PADMA (calculated from recommended human daily dose) or 0.085 mg (dose in the range of active doses of other herbal extracts studied by us previously).
Results.
Highly significant increase of newly formed blood vessels number in ex vivo cutaneous lymphocyte-induced angiogenesis test (LIA) after grafting of Balb/c splenocytes from both dosage groups to F1 hybrids (Balb/c × C3H); increase of blood lymphocytes and granulocytes number only in mice fed with lower dose of remedy; and significant suppression of metabolic activity (chemiluminescence test) of blood granulocytes in mice fed with higher dose of PADMA.
Conclusion.
PADMA 28 behaves as a good stimulator of physiological angiogenesis, but for this purpose it should be used in substantially lower doses than recommended by producers for avoiding the deterioration of granulocyte function.
American Psychological Association (APA)
Radomska-Leśniewska, Dorota M.& Skopiński, Piotr& Niemcewicz, Marcin& Zdanowski, Robert& Lewicki, Sławomir& Kocik, Janusz…[et al.]. 2013. The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503506
Modern Language Association (MLA)
Radomska-Leśniewska, Dorota M.…[et al.]. The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-503506
American Medical Association (AMA)
Radomska-Leśniewska, Dorota M.& Skopiński, Piotr& Niemcewicz, Marcin& Zdanowski, Robert& Lewicki, Sławomir& Kocik, Janusz…[et al.]. The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503506