Novel Functional Aspect of Antihistamines : The Impact of Bepotastine Besilate on Substance P-Induced Events
Joint Authors
Katayama, Ichiro
Murota, Hiroyuki
Azukizawa, Hiroaki
Kitaba, Shun
Yahata, Yoko
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Besides histamine, substance P (SP) has been demonstrated to play a crucial role in pruritic skin diseases.
Although antihistamines are frequently used for pruritic skin diseases, little is known concerning the effect on an SP-induced event such as mast cell degranulation and the upregulation of adhesion molecules or the nitric oxide (NO) synthesis in endothelial cells.
Our aim was to study the effect of bepotastine besilate on SP-induced degranulation of rat basophillic leukemia (RBL-2H3) cells and expression of adhesion molecules and NO synthesis in human dermal microvascular endothelial cells (HMVECs).
Bepotastine besilate significantly inhibited SP-induced degranulation of RBL-2H3 cells and NO synthesis in HMVECs.
Bepotastine besilate significantly inhibited expression of adhesion molecules in HMVESs, while it failed to suppress SP-induced upregulation of the adhesion molecules in HMVECs.
Therefore, bepotastine besilate is assumed to act favorably on SP-induced basophil degranulation and NO synthesis in HMVECs.
American Psychological Association (APA)
Kitaba, Shun& Murota, Hiroyuki& Yahata, Yoko& Azukizawa, Hiroaki& Katayama, Ichiro. 2009. Novel Functional Aspect of Antihistamines : The Impact of Bepotastine Besilate on Substance P-Induced Events. Journal of Allergy،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-503531
Modern Language Association (MLA)
Kitaba, Shun…[et al.]. Novel Functional Aspect of Antihistamines : The Impact of Bepotastine Besilate on Substance P-Induced Events. Journal of Allergy No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-503531
American Medical Association (AMA)
Kitaba, Shun& Murota, Hiroyuki& Yahata, Yoko& Azukizawa, Hiroaki& Katayama, Ichiro. Novel Functional Aspect of Antihistamines : The Impact of Bepotastine Besilate on Substance P-Induced Events. Journal of Allergy. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-503531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503531