Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis
Joint Authors
Orr, A. Wayne
Alexander, Jonathan Steven
Chen, Jie
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis.
Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin family of extracellular matrix receptors.
However, the propensity for some tumors to spread through lymphatics suggests that lymphangiogenesis plays a similarly important role.
Lymphangiogenesis inhibitors reduce lymph node metastasis, the leading indicator of poor prognosis, whereas inducing lymphangiogenesis promotes lymph node metastasis even in cancers not prone to lymphatic dissemination.
Recent works highlight a role for integrins in lymphangiogenesis and suggest that integrin inhibitors may serve as therapeutic targets to limit lymphangiogenesis and lymph node metastasis.
This review discusses the current literature on integrin-matrix interactions in lymphatic vessel development and lymphangiogenesis and highlights our current knowledge on how specific integrins regulate tumor lymphangiogenesis.
American Psychological Association (APA)
Chen, Jie& Alexander, Jonathan Steven& Orr, A. Wayne. 2012. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503535
Modern Language Association (MLA)
Chen, Jie…[et al.]. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis. International Journal of Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-503535
American Medical Association (AMA)
Chen, Jie& Alexander, Jonathan Steven& Orr, A. Wayne. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503535