Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

Joint Authors

Orr, A. Wayne
Alexander, Jonathan Steven
Chen, Jie

Source

International Journal of Cell Biology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-02-12

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis.

Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin family of extracellular matrix receptors.

However, the propensity for some tumors to spread through lymphatics suggests that lymphangiogenesis plays a similarly important role.

Lymphangiogenesis inhibitors reduce lymph node metastasis, the leading indicator of poor prognosis, whereas inducing lymphangiogenesis promotes lymph node metastasis even in cancers not prone to lymphatic dissemination.

Recent works highlight a role for integrins in lymphangiogenesis and suggest that integrin inhibitors may serve as therapeutic targets to limit lymphangiogenesis and lymph node metastasis.

This review discusses the current literature on integrin-matrix interactions in lymphatic vessel development and lymphangiogenesis and highlights our current knowledge on how specific integrins regulate tumor lymphangiogenesis.

American Psychological Association (APA)

Chen, Jie& Alexander, Jonathan Steven& Orr, A. Wayne. 2012. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503535

Modern Language Association (MLA)

Chen, Jie…[et al.]. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis. International Journal of Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-503535

American Medical Association (AMA)

Chen, Jie& Alexander, Jonathan Steven& Orr, A. Wayne. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503535

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-503535