Serum Leptin Levels in Pemphigus : A Case Control Study
Joint Authors
Mozafari, Nikoo
Younespour, Shima
Robati, Reza M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Pemphigus is an autoimmune blistering disease mediated by autoantibodies directed against keratinocyte adhesion molecules.
Leptin, an adipocyte-derived hormone, plays a role in immune responses and promotes autoimmunity.
Objectives.
This study was conducted to determine whether serum leptin levels are altered in pemphigus patients and whether there is any correlation between leptin levels and the severity of disease.
Methods.
This study included 47 newly diagnosed patients with pemphigus and 43 age- and sex-matched healthy controls.
Clinical characteristics and pemphigus area and activity score (PAAS) were assessed.
Serum leptin levels (ng/mL) were measured by a commercial enzyme-linked immunosorbent assay (ELISA).
Results.
Patients did not differ significantly in serum leptin levels from healthy controls (median (range): 10.8 (0.1–110) ng/mL versus 12 (0.5–69.9) ng/mL and P=0.53).
There was no significant association between serum leptin concentrations and severity of disease measured by PAAS (rs=0.06, P=0.70).
Conclusion.
The results suggest that pemphigus does not have a direct influence on serum leptin levels and the pathogenesis of pemphigus seems to be not dependent on the connection with adipose tissue.
American Psychological Association (APA)
Mozafari, Nikoo& Robati, Reza M.& Younespour, Shima. 2014. Serum Leptin Levels in Pemphigus : A Case Control Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-503536
Modern Language Association (MLA)
Mozafari, Nikoo…[et al.]. Serum Leptin Levels in Pemphigus : A Case Control Study. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-503536
American Medical Association (AMA)
Mozafari, Nikoo& Robati, Reza M.& Younespour, Shima. Serum Leptin Levels in Pemphigus : A Case Control Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-503536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503536