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Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis
Joint Authors
Grayaa, Rahma
Maaloul, Aya
Kharoubi, Wafa
Mahjoub, Touhami
Hammami, Mohamed
Jrah Harzallah, Hanene
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats.
Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted.
The TQ pretreatment restored the parameters cited above to near-normal values.
However, the posttreatment shows an activity similar as that presented by DMH.
Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages.
American Psychological Association (APA)
Jrah Harzallah, Hanene& Grayaa, Rahma& Kharoubi, Wafa& Maaloul, Aya& Hammami, Mohamed& Mahjoub, Touhami. 2012. Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-503577
Modern Language Association (MLA)
Jrah Harzallah, Hanene…[et al.]. Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-503577
American Medical Association (AMA)
Jrah Harzallah, Hanene& Grayaa, Rahma& Kharoubi, Wafa& Maaloul, Aya& Hammami, Mohamed& Mahjoub, Touhami. Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-503577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503577