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Urine Annexin A1 as an Index for Glomerular Injury in Patients
Joint Authors
Tsai, Pei-Yi
Ka, Shuk-Man
Shui, Hao-Ai
Chen, Jin-Shuen
Yang, Shun-Min
Chen, Ann
Hung, Yi-Jen
Chao, Tai-Kuang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
We recently demonstrated high urine levels of annexin A1 (ANXA1) protein in a mouse Adriamycin-induced glomerulopathy (ADG) model.
Objective.
To establish ANXA1 as a potential biomarker for glomerular injury in patients.
Methods.
A time-course study in the mouse ADG model, followed by renal tissues and urine samples from patients with various types of glomerular disorders for ANXA1.
Results.
Urinary ANXA1 protein was (1) detectable in both the ADG model and in patients except those with minimal change disease (MCD); (2) positively correlated with renal lesions in patients; and (3) early detectable in diabetes patients with normoalbuminuria.
Conclusions.
ANXA1 is a universal biomarker that is helpful in the early diagnosis, prognostic prediction, and outcome monitoring of glomerular injury.
Measurement of urinary ANXA1 protein levels can help in differentiating MCD from other types of glomerular disorders.
American Psychological Association (APA)
Ka, Shuk-Man& Tsai, Pei-Yi& Chao, Tai-Kuang& Yang, Shun-Min& Hung, Yi-Jen& Chen, Jin-Shuen…[et al.]. 2014. Urine Annexin A1 as an Index for Glomerular Injury in Patients. Disease Markers،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-503593
Modern Language Association (MLA)
Ka, Shuk-Man…[et al.]. Urine Annexin A1 as an Index for Glomerular Injury in Patients. Disease Markers No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-503593
American Medical Association (AMA)
Ka, Shuk-Man& Tsai, Pei-Yi& Chao, Tai-Kuang& Yang, Shun-Min& Hung, Yi-Jen& Chen, Jin-Shuen…[et al.]. Urine Annexin A1 as an Index for Glomerular Injury in Patients. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-503593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503593