Novel Organotin(IV)‎-Schiff Base Complexes : Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies

Abstract EN

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies.

The synthesized compounds were tested for antimicrobial activity by disc diffusion method.

The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA.

Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis.

The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions.

The gel was run both in the absence and presence of the oxidizing agent.