Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder
Joint Authors
Zhang, Hong
Sun, Taotao
Hu, Shu
Fan, Rong
Jia, Shaowe
Sun, Wen
Hou, Haifeng
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased.
However, the neurobiological mechanism of IAD has not bee fully expressed.
The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by T99mc-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD.
SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls.
The volume (V) and weight (W) of bilateral corpus striatum as well as the T99mc-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models.
It was displayed that DAT expression level of striatum was significantly decreased and the V, W, and Ra were greatly reduced in the individuals with IAD compared to controls.
Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems.
Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders.
American Psychological Association (APA)
Hou, Haifeng& Jia, Shaowe& Hu, Shu& Fan, Rong& Sun, Wen& Sun, Taotao…[et al.]. 2012. Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503614
Modern Language Association (MLA)
Hou, Haifeng…[et al.]. Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-503614
American Medical Association (AMA)
Hou, Haifeng& Jia, Shaowe& Hu, Shu& Fan, Rong& Sun, Wen& Sun, Taotao…[et al.]. Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503614