Intereleukin-10 Promoter Polymorphism in Mild Cognitive Impairment and in Its Clinical Evolution
Joint Authors
Annoni, Giorgio
Arosio, Beatrice
Vergani, Carlo
Mastronardi, Luigina
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Specific proinflammatory alleles are associated with higher risk of Alzheimer disease (AD) in different onset age.
The homozygosis for the A allele of −1082 polymorphism (G/A) of interleukin-10 (IL-10) promotes a higher risk of AD and reduced IL-10 generation in peripheral cells after amyloid stimulation.
In this paper we analysed genotype and allele frequencies of this polymorphism in 138 subjects with mild cognitive impairment (MCI) diagnosed, respectively, as amnestic (a-MCI) and multiple impaired cognitive domains (mcd-MCI).
The genotype frequencies were similar in a-MCI and AD subjects, whereas in mcd-MCI comparable to controls (AA genotype: 50% in a-MCI, 49.2% in AD, 28.7% in mcd-MCI and 31.8% in controls).
Consequently, both allele and genotype distributions were significantly different between a-MCI and mcd-MCI (allele: P=.02, genotype: P<.05).
These results support the theory that polymorphisms of cytokine genes can affect neurodegeneration and its clinical progression.
IL-10 may partly explain the conversion of a-MCI to AD or be a genetic marker of susceptibility.
American Psychological Association (APA)
Arosio, Beatrice& Mastronardi, Luigina& Vergani, Carlo& Annoni, Giorgio. 2010. Intereleukin-10 Promoter Polymorphism in Mild Cognitive Impairment and in Its Clinical Evolution. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-503616
Modern Language Association (MLA)
Arosio, Beatrice…[et al.]. Intereleukin-10 Promoter Polymorphism in Mild Cognitive Impairment and in Its Clinical Evolution. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-503616
American Medical Association (AMA)
Arosio, Beatrice& Mastronardi, Luigina& Vergani, Carlo& Annoni, Giorgio. Intereleukin-10 Promoter Polymorphism in Mild Cognitive Impairment and in Its Clinical Evolution. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-503616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503616