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Paternal Smoking and Risk of Childhood Acute Lymphoblastic Leukemia : Systematic Review and Meta-Analysis
Joint Authors
McHale, Cliona M.
Liu, Ruiling
Hammond, S. Katharine
Zhang, Luoping
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Objective.
To investigate the association between paternal smoking and childhood acute lymphoblastic leukemia (ALL).
Method.
We identified 18 published epidemiologic studies that reported data on both paternal smoking and childhood ALL risk.
We performed a meta-analysis and analyzed dose-response relationships on ALL risk for smoking during preconception, during pregnancy, after birth, and ever smoking.
Results.
The summary odds ratio (OR) of childhood ALL associated with paternal smoking was 1.11 (95% Confidence Interval (CI): 1.05–1.18, I2=18%) during any time period, 1.25 (95% CI: 1.08–1.46, I2=53%) preconception; 1.24 (95% CI: 1.07–1.43, I2=54%) during pregnancy, and 1.24 (95% CI: 0.96–1.60, I2=64%) after birth, with a dose-response relationship between childhood ALL and paternal smoking preconception or after birth.
Conclusion.
The evidence supports a positive association between childhood ALL and paternal ever smoking and at each exposure time period examined.
Future epidemiologic studies should assess paternal smoking during well-defined exposure windows and should include biomarkers to assess smoking exposure and toxicological mechanisms.
American Psychological Association (APA)
Liu, Ruiling& Zhang, Luoping& McHale, Cliona M.& Hammond, S. Katharine. 2011. Paternal Smoking and Risk of Childhood Acute Lymphoblastic Leukemia : Systematic Review and Meta-Analysis. Journal of Oncology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-503621
Modern Language Association (MLA)
Liu, Ruiling…[et al.]. Paternal Smoking and Risk of Childhood Acute Lymphoblastic Leukemia : Systematic Review and Meta-Analysis. Journal of Oncology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-503621
American Medical Association (AMA)
Liu, Ruiling& Zhang, Luoping& McHale, Cliona M.& Hammond, S. Katharine. Paternal Smoking and Risk of Childhood Acute Lymphoblastic Leukemia : Systematic Review and Meta-Analysis. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-503621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503621