Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum
Joint Authors
Tordrup, David
D'Annessa, Ilda
Knudsen, Birgitta Ruth
Desideri, Alessandro
Laursen, Rune R.
Roy, Amit
Andersen, Felicie Faucon
Nielsen, Christine J. F.
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Control of diseases inflicted by protozoan parasites such as Leishmania, Trypanosoma, and Plasmodium, which pose a serious threat to human health worldwide, depends on a rather small number of antiparasite drugs, of which many are toxic and/or inefficient.
Moreover, the increasing occurrence of drug-resistant parasites emphasizes the need for new and effective antiprotozoan drugs.
In the current study, we describe a synthetic peptide, WRWYCRCK, with inhibitory effect on the essential enzyme topoisomerase I from the malaria-causing parasite Plasmodium falciparum.
The peptide inhibits specifically the transition from noncovalent to covalent DNA binding of P.
falciparum topoisomerase I, while it does not affect the ligation step of catalysis.
A mechanistic explanation for this inhibition is provided by molecular docking analyses.
Taken together the presented results suggest that synthetic peptides may represent a new class of potential antiprotozoan drugs.
American Psychological Association (APA)
Roy, Amit& D'Annessa, Ilda& Nielsen, Christine J. F.& Tordrup, David& Laursen, Rune R.& Knudsen, Birgitta Ruth…[et al.]. 2011. Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Molecular Biology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503625
Modern Language Association (MLA)
Roy, Amit…[et al.]. Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Molecular Biology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-503625
American Medical Association (AMA)
Roy, Amit& D'Annessa, Ilda& Nielsen, Christine J. F.& Tordrup, David& Laursen, Rune R.& Knudsen, Birgitta Ruth…[et al.]. Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503625