Purification and Characterization of a Mitogenic Lectin from Cephalosporium, a Pathogenic Fungus Causing Mycotic Keratitis
Joint Authors
Chachadi, Vishwanath B.
Inamdar, Shashikala R.
Shubhada, C.
Nagre, Nagaraja N.
Pujari, Radha
Swamy, Bale M.
Shastry, Padma
Eligar, Sachin M.
Source
Biochemistry Research International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ophthalmic mycoses caused by infectious fungi are being recognized as a serious concern since they lead to total blindness.
Cephalosporium is one amongst several opportunistic fungal species implicated in ophthalmic infections leading to mycotic keratitis.
A mitogenic lectin has been purified from the mycelia of fungus Cephalosporium, isolated from the corneal smears of a keratitis patient.
Cephalosporium lectin (CSL) is a tetramer with subunit mass of 14 kDa, agglutinates human A, B, and O erythrocytes, and exhibits high affinity for mucin compared to fetuin and asialofetuin but does not bind to simple sugars indicating its complex sugar specificity.
CSL showed strong binding to normal human peripheral blood mononuclear cells (PBMCs) to elicit mitogenic activity.
The sugar specificity of the lectin and its interaction with PBMCs to exhibit mitogenic effect indicate its possible role in adhesion and infection process of Cephalosporium.
American Psychological Association (APA)
Nagre, Nagaraja N.& Chachadi, Vishwanath B.& Eligar, Sachin M.& Shubhada, C.& Pujari, Radha& Shastry, Padma…[et al.]. 2010. Purification and Characterization of a Mitogenic Lectin from Cephalosporium, a Pathogenic Fungus Causing Mycotic Keratitis. Biochemistry Research International،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-503633
Modern Language Association (MLA)
Nagre, Nagaraja N.…[et al.]. Purification and Characterization of a Mitogenic Lectin from Cephalosporium, a Pathogenic Fungus Causing Mycotic Keratitis. Biochemistry Research International No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-503633
American Medical Association (AMA)
Nagre, Nagaraja N.& Chachadi, Vishwanath B.& Eligar, Sachin M.& Shubhada, C.& Pujari, Radha& Shastry, Padma…[et al.]. Purification and Characterization of a Mitogenic Lectin from Cephalosporium, a Pathogenic Fungus Causing Mycotic Keratitis. Biochemistry Research International. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-503633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503633