Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation
Joint Authors
Lin, Pao-Yuan
Wei, Fu-Chan
Kuo, Yur-Ren
Chen, Chao-Long
Chen, Chien-Chang
Goto, Shigeru
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Vascularized composite allotransplantations (VCAs) are not routinely performed for tissue reconstruction because of the potentially harmful adverse effects associated with lifelong administration of immunosuppressive agents.
Researchers have been eagerly seeking alternative methods that circumvent the long-term use of immunosuppressants.
Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection.
The mechanisms by which MSCs modulate the immune response are still under thorough investigation, but these most likely involve expression of local factors influencing T-cell regulation, modulation of cytokine expression (e.g., IL-10, TGF-β, TNF-α, INF-γ, etc.), and interactions with dendritic or antigen presenting cells.
In this paper, we summarize the current understanding of immunomodulation achieved by MSC therapies and introduce a possible outline for future clinical applications in VCA.
American Psychological Association (APA)
Kuo, Yur-Ren& Chen, Chien-Chang& Goto, Shigeru& Lin, Pao-Yuan& Wei, Fu-Chan& Chen, Chao-Long. 2012. Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503663
Modern Language Association (MLA)
Kuo, Yur-Ren…[et al.]. Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-503663
American Medical Association (AMA)
Kuo, Yur-Ren& Chen, Chien-Chang& Goto, Shigeru& Lin, Pao-Yuan& Wei, Fu-Chan& Chen, Chao-Long. Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503663